Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

作者：Balestrieri Emanuela; Pizzimenti Francesco; Ferlazzo Angelo; Giofre Salvatore V; Iannazzo Daniela; Piperno Anna^*; Romeo Roberto; Chiacchio Maria Assunta; Mastino Antonio; Macchi Beatrice

来源：Bioorganic & Medicinal Chemistry, 2011, 19(6): 2084-2089.

DOI：10.1016/j.bmc.2011.01.024

• Natural products
• Bergamot
• Limonoids
• Antiretrovirals
• HIV
• HTLV-1
• Reverse transcriptase

The effects of an extract from Citrus bergamia (BSext) and those of two products purified from the same extract, that is, nomilin and limonin, and reference compounds, towards HTLV-1 have been reported. Moreover, they were also compared with those obtained towards HIV-1. Results showed that the efficacy of both BSext and limonin in inhibiting HTLV-1 as well as HIV-1 expression in infected cells, as evaluated by comparable quantitative assays, was close to that of the effective, reference compounds, respectively. The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays. The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product.

• 出版日期2011-3-15