Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice

作者:Li, Juane; Liu, Tonghua*; Wang, Lei; Guo, Xiangyu; Xu, Tunhai; Wu, Lili; Qin, Lingling; Sun, Wen
来源:Journal of Traditional Chinese Medicine, 2012, 32(3): 446-452.
DOI:10.1016/S0254-6272(13)60053-9

摘要

OBJECTIVE: To investigate the effects of cinnamaldehyde (CA), an active and major compound in cinnamon, on glucose metabolism and insulin resistance in C57BLKS/J db/db mice. METHODS: Sixteen male C57BLKS db/db mice were randomly divided into control and CA treatment groups. CA was given (20 mg.kg(-1).day(-1), p.o.) for 4 weeks. Pure water was given to control and db/+ mice. Subsequently, the levels of fasting blood glucose (FBG), fasting serum insulin, triglyeride, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and free fatty acids (FFA), as well as the mRNA content of adiponectin and tumor necrosis factor (TNF)-alpha in adipose tissue, glucose transporter type 4 (GLUT-4) in skeletal muscle, and protein expressions of Akt, phospho-Akt (Thr308), AMPK alpha, phospho-AMPK alpha (Thr172) in skeletal muscle were measured. RESULTS: 1) CA decreased serum levels of FBG and insulin as well as body weight in db/db mice; 2) CA increased serum HDL-C levels; 3) CA significantly decreased the mRNA expression of TNF-alpha in adipose tissue and upregulated mRNA expression of GLUT-4 in skeletal muscle; 4) protein expression of p-Akt was increased in CA-treated mice, but Akt, AMPKa and p-AMPK alpha showed no change. CONCLUSION: CA has antihyperglycemic and antihyperlipidemic actions in db/db mice and could be useful in the treatment of type-2 diabetes.