A photoCORM nanocarrier for CO release using NIR light

作者：Pierri, Agustin E.; Huang, Po-Ju; Garcia, John V.; Stanfill, James G.; Chui, Megan; Wu, Guang; Zheng, Nanfeng^*; Ford, Peter C.

来源：Chemical communications, 2015, 51(11): 2072-2075.

DOI：10.1039/c4cc06766e

• NITRIC-OXIDE RELEASE
• CARBON-MONOXIDE
• NITROSYL COMPLEX
• VISIBLE-LIGHT
• THERAPY
• NANOPARTICLES
• EXCITATION
• DELIVERY

A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)(2)(CO)(2). Such an ensemble offers a unique strategy for CO delivery to biological targets.

• 出版日期2015
• 单位厦门大学