Association between GABA(A) Receptor Subunit Gene Cluster and Zolpidem-Induced Complex Sleep Behaviors in Han Chinese

作者：Tsai Jui Hsiu; Yang Pinchen; Lin Hung Hsun; Cheng Kuang hung; Yang Yi Hsin; Wu Ming Tsang; Chen Cheng Chung^*

来源：Sleep, 2013, 36(2): 197-202.

DOI：10.5665/sleep.2372

• Genetic marker
• complex sleep behaviors
• zolpidem
• GABA(A) receptor

Study Objectives: To investigate and elucidate the role of GABA(A) receptor subunits, specifically the 2 genetic markers at the GABA(A) alpha 1 and GABA(A) alpha 6 receptors, in zolpidem-induced complex sleep behaviors (CSBs). %26lt;br%26gt;Design: Genetic association study. %26lt;br%26gt;Setting: Kaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan. %26lt;br%26gt;Patients: 30 zolpidem-induced CSB subjects and 37 controls. %26lt;br%26gt;Interventions: N/A. %26lt;br%26gt;Measurements and Results: The chi(2) test demonstrated an association between the A15G variant at the GABA(A) alpha 1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABA(A) alpha 1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013). %26lt;br%26gt;Conclusions: The finding reveals that the A15G variant at the GABA(A) alpha 1 receptor subunit gene confers a high risk of zolpidem-induced CSBs and may be considered in clinical services.

• 出版日期2013-2-1
• 单位中山大学