Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years

作者：Clark Erin A S^*; Mele Lisa; Wapner Ronald J; Spong Catherine Y; Sorokin Yoram; Peaceman Alan; Iams Jay D; Leveno Kenneth J; Harper Margaret; Caritis Steve N; Miodovnik Menachem; Mercer Brian M; Thorp John M; Ramin Susan M; Carpenter Marshall; Rouse Dwight J

来源：American Journal of Obstetrics and Gynecology, 2010, 203(1): 83.e1.

DOI：10.1016/j.ajog.2010.01.047

• gene polymorphism
• neurodevelopmental delay
• single-nucleotide polymorphism

OBJECTIVE: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years.
STUDY DESIGN: We conducted a case-controlled secondary analysis of a randomized trial of single-vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment.
RESULTS: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL) 1 beta-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1 beta-511 (P = .03) and IL6-174 (P = .04). Results for IL1 beta-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1 beta-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9).
CONCLUSION: Fetal SNPs in IL1 beta, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.

• 出版日期2010-7
• 单位西北大学