Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

作者：Andronesi Ovidiu C^*; Rapalino Otto; Gerstner Elizabeth; Chi Andrew; Batchelor Tracy T; Cahil Dan P; Sorensen A Gregory; Rosen Bruce R

来源：Journal of Clinical Investigation, 2013, 123(9): 3659-3663.

DOI：10.1172/JCI67229

The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.

• 出版日期2013-9