A new interface used to couple capillary electrophoresis with inductively coupled plasma mass spectrometry for speciation analysis

作者：Yang GuiDi; Xu XueQin; Wang Wei; Xu LiangJun; Chen GuoNan; Fu FengFu^*

来源：Electrophoresis, 2008, 29(13): 2862-2868.

DOI：10.1002/elps.200700849

• arsenic
• capillary electrophoresis
• inductively coupled plasma mass spectrometry
• speciation analysis

In this work, a novel and high-efficiency interface has been developed in coupling CE with inductively coupled plasma MS (ICPMS). The interface completely avoids laminar flow in CE capillary caused by the suction of nebulizer, and can be easily and stably operated at room temperature with high analyte transport efficiency to ICPMS. The new interface has a liquid dead volume smaller than 5 nL, which was much smaller than those (65-2500 mu L) reported previously for other interfaces. All above features led to a higher sensitivity and a better electrophoretic resolution for CE-ICPMS coupled with this new interface. With the help of this new interface, we have successfully separated and determined five species of arsenic, As (111), As (V), monomethylarsonic acid, dimethylarsinic acid and p-aminophenylarsonic acid using CE-ICPMS within 11 min with a detection limit of 0.046-0.075 ng/mL and an RSD of 2-6% (n = 6).

• 出版日期2008-7
• 单位福州大学; 福建农林大学