A water soluble and fast response fluorescent turn-on copper complex probe for H2S detection in zebra fish

作者：Palanisamy Sathyadevi; Lee Lu Ying; Wang Yu Liang; Chen Yu Jen; Chen Chiao Yun^*; Wang Yun Ming

来源：Talanta, 2016, 147: 445-452.

DOI：10.1016/j.talanta.2015.10.019

• MaT-cyclen
• H2S detection
• Confocal
• Zebra fish

According to the displacement method, herein we reported a water soluble copper complex [Cu(MaT-cyclen)(2)] as a fluorescent probe for the detection of H2S. For this, 1((1-(10-methylanthracen-9-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,7,10-tetraazacyclododecane (MaT-cyclen) was synthesized first To improve its solubility in aqueous media, sodium acetate group was introduced into 8-hydroxy-2-quinoline successfully. MaT-cyclen was chelated with Cu(II) to form [Cu(MaT-cyclen)2] complex, which displayed high sensitivity and selectivity for H2S over the other possible competitive substances on the basis of forming CuS. Meanwhile, [Cu(MaT-cyclen)(2)] displayed rapid response (< 1 min), well reversibility, lowest detection limit (205 nM), and high sensitivity for recognizing H2S in aqueous solution. Furthermore, its potential utility for biological applications was confirmed by fluorescence imaging of H2S in live cells as well as in zebra fish.

• 出版日期2016-1-15