Neuroinflammation and Memory: The Role of Prostaglandins

作者：Hein Amy M; O'Banion M Kerry^*

来源：Molecular Neurobiology, 2009, 40(1): 15-32.

DOI：10.1007/s12035-009-8066-z

• Neuroinflammation
• Prostaglandins
• Learning
• Memory
• Hippocampus
• Cyclooxygenase
• NSAID
• Lipopolysaccharide
• Traumatic brain injury
• Aging
• Alzheimer's disease

Neuroinflammation is a complex response to brain injury involving the activation of glia, release of inflammatory mediators within the brain, and recruitment of peripheral immune cells. Interestingly, memory deficits have been observed following many inflammatory states including infection, traumatic brain injury (TBI), normal aging, and Alzheimer's disease (AD). Prostaglandins (PGs), a class of lipid mediators which can have inflammatory actions, are upregulated by these inflammatory challenges and can impair memory. In this paper, we critically review the success of nonsteroidal anti-inflammatory drugs, which prevent the formation of PGs, in preventing neuroinflammation-induced memory deficits following lipopolysaccharide injection, TBI, aging, and experimental models of AD in rodents and propose a mechanism by which PGs could disrupt memory formation.

• 出版日期2009-8