Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea

作者：Lee, Chia Lin; Liao, Yung Chih; Hwang, Tsong Long; Wu, Chin Chung; Chang, Fang Rong^*; Wu, Yang Chang

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(24): 7354-7357.

DOI：10.1016/j.bmcl.2010.10.058

• Ixora coccinea
• Rubiaceae
• Ixorapeptide I
• Ixorapeptide II
• Anti-cytotoxicity
• Anti-inflammation
• Anti-platelet aggregation

Two novel derivatized peptides, designated as ixorapeptide I (1) and ixorapeptide II (2), in addition to 28 other known compounds, were isolated from the MeOH extract of Ixora coccinea using bioassay-guided fractionation. The structures of metabolites 1 and 2 were determined by interpretation of the spectroscopic data and Marfey's method. Compound 1 exhibited selective potency against Hep3B liver cancer cell line with an IC50 value of 3.36 mu g/mL, and compound 2 did not show notable cytotoxicity toward cancer cell lines but could inhibit superoxide anion generation and elastase release with IC50 values of 0.21 and 0.27 mu g/mL, respectively. Moreover, kaempferol and luteolin from this plant showed inhibition with IC50 values of 3.55 and 2.56 mu g/mL, respectively on platelet aggregation induced by collagen.

• 出版日期2010-12-15
• 单位长春大学; 中国医科大学; 中山大学