Atopic Dermatitis in Children Clinical Features, Pathophysiology, and Treatment

作者：Lyons Jonathan J; Milner Joshua D; Stone Kelly D^*

来源：Immunology and Allergy Clinics of North America, 2015, 35(1): 161-+.

DOI：10.1016/j.iac.2014.09.008

• Atopic dermatitis
• Eczema
• Allergy
• Netherton syndrome
• Hyper-IgE syndrome

Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution, and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.

• 出版日期2015-2