Comparison of intravaginal progesterone gel and intramuscular 17-alpha-hydroxyprogesterone caproate in luteal phase support

作者：Satir Funda; Toptas Tayfun^*; Inel Murat; Erman Akar Munire; Taskin Omur

来源：Experimental and Therapeutic Medicine, 2013, 5(6): 1740-1744.

DOI：10.3892/etm.2013.1049

• intravaginal progesterone gel
• 17-alpha-hydroxyprogesterone
• luteal phase support

The main objective of this study was to compare the pregnancy rates of intramuscular (IM) 17-alpha-hydroxyprogesterone caproate (17-HPC) and intravaginal (IV) progesterone gel administration in in vitro fertilization-embryo transfer (IVF-ET) cycles. The IM 17-HPC and IV progesterone groups included 632 (66.4%) and 320 (33.6%) women undergoing the first cycles of IVF-ET treatment, respectively. Multivariate analyses annotated for all potential confounders showed that the use of IV progesterone retained a predictive value for the total beta-human chorionic gonadotropin (hCG) positivity and clinical pregnancy rates [adjusted odds ratio (OR), 1.97; 95% confidence interval (CI), 1.28-3.03; P=0.002; and OR, 1.66; 95% CI, 1.07-2.60; P=0.03, respectively]. However, biochemical and on-going pregnancy rates did not differ significantly between the groups (OR, 1.85; 95% CI, 1.00-3.41; P=0.05; and OR, 1.43, 95% CI, 0.89-2.30; P=0.14, respectively). Luteal phase support (LPS) with IV progesterone gel in comparison with IM 17-HPC appears to be associated with higher clinical pregnancy rates in IVF-ET cycles. However, this benefit is clinically irrelevant in terms of on-going pregnancy outcomes.

• 出版日期2013-6