Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content

作者：Munoz Karen E; Meyer Lindenberg Andreas; Hariri Ahmad R; Mervis Carolyn B; Mattay Venkata S; Morris Colleen A; Berman Karen Faith^*

来源：NeuroImage, 2010, 50(1): 340-346.

DOI：10.1016/j.neuroimage.2009.11.069

Williams syndrome (WS) is a rare genetic disorder caused by the deletion of similar to 25 genes on chromosome 7q11.23 and is characterized by both hypersociability and increases in specific phobia and anticipatory anxiety regarding non-social entities or circumstances. Alterations in amygdala reactivity and prefrontal regulation consistent with the observed behavioral pattern of social versus non-social abnormalities have been previously demonstrated in individuals with WS ( Meyer-Lindenberg et al., 2005). However, in that study, the social stimulus (faces) matching task was more difficult than the non-social scene (IAPS stimuli) matching task, making it impossible to disambiguate the relative contributions of task difficulty and stimulus type (social versus non-social). In the present study, we examined the performance of the same group of participants with WS and normal IQs during a more cognitively demanding task using the same scene stimuli as in the prior study. Confirming previous findings, the results indicated (a) a differential response of prefrontal regions as a function of task difficulty and (b) a persistently increased activation of the amygdala to non-social scenes by individuals with WS regardless of cognitive load. These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS.

• 出版日期2010-3