Antibody persistence 1 year after pandemic H1N1 2009 influenza vaccination and immunogenicity of subsequent seasonal influenza vaccine among adult organ transplant patients

作者：Felldin Marie^*; Andersson Bengt; Studahl Marie; Svennerholm Bo; Friman Vanda

来源：Transplant International, 2014, 27(2): 197-203.

DOI：10.1111/tri.12237

• antibody response
• cellular immune response
• influenza A H11/09 vaccination
• organ transplantation
• trivalent influenza vaccine TIV/10

We investigated the antibody persistence in solid organ transplant (SOT) recipients 1year after immunization with two doses of monovalent AS03-adjuvanted influenza A(H1N1)pdm09 vaccine. We also assessed the boosting effect of the seasonal trivalent inactivated vaccine 2010 (TIV/10) that contained the influenza A(H1N1)pdm09 strain. A total of 49 SOT recipients and 11 healthy controls were included. After a blood sample was obtained to assess the persistent immunity, one dose of TIV/10 was administered and another blood sample was collected 1month after vaccination. A(H1N1)pdm09 antibodies were measured using a haemagglutination inhibition assay. The percentage of SOT recipients with protective titres decreased between 1month and 10-14months after the monovalent influenza A(H1N1)pdm09 vaccination, from 79% (n=38) to 47% (n=23) (P=0.02). The corresponding numbers for the control group were 100% and 63%, respectively (P=0.008). After the TIV/10 boosting dose, the number of SOT recipients with protective titres increased from 47% (n=23) to 71% (n=35) (P=0.2). All the controls reached a protective titre level. The median titre rise was significantly higher among controls when compared to SOT recipients (P=0.0036). No rejection or adverse events were seen. The results show an obvious need for vaccine boosting doses in the SOT patients. (ClinicalTrials.gov number: NCT01256931).

• 出版日期2014-2