Automatic and Simple Method for Tc-99 Determination Using a Selective Resin and Liquid Scintillation Detection Applied to Urine Samples

作者：Villar Marina; Avivar Jessica; Ferrer Laura; Galmes Margalida; Vega Fernando; Cerda Victor^*

来源：Analytical Chemistry, 2013, 85(11): 5491-5498.

DOI：10.1021/ac4006217

Tc-99m (6.0067 h half-life) is an artificial radionuclide largely used in diagnostic medicine. Its daughter Tc-99 is a beta emitter of great concern long half-life (2.111 x 10(5) years) and presumed mobile behavior in the environment. To monitor the Tc-99 in urine from treated patients, an automatic Lab-on-valve (LOV) system for separation and preconcentration of Tc-99 was developed. TEVA resin as selected since it retains pertechnetate ion selectively from diluted nitric acid solutions After elution, Tc-99 is detected using a liquid scintillation counting (LSC) detector. The. present method has been successfully applied to urine samples with low Tc-99 content (recoveries between 94-111%). The minimum detectable activity (MDA) of h developed method is 0.1 Bq or 1 Bq L-1 (expressed as activity concentration The concentration), when preconcentrating 100 mL of sample. The high durability of the resin, together with the low amount of of resin required (32 mg), the good reproducibility (RSD 2% n = 5) and extraction frequency (up to 12 h(-1)) makes of the present metho inexpensive, precise and fast useful tool for monitoring Tc-99 in urine samples.

• 出版日期2013-6-4