Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives

作者：Basaric Nikola^*; Sohora Margareta; Cindro Nikola; Mlinaric Majerski Kata; De Clercq Erik; Balzarini Jan

来源：Archiv der Pharmazie, 2014, 347(5): 334-340.

DOI：10.1002/ardp.201300345

• Adamantanes
• Antiproliferative activity
• Antiviral activity
• Phthalimides
• Polycyclic compounds
• Unnatural amino acids

Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.

• 出版日期2014-5