A novel and highly efficient method for the silylation of alcohols with hexamethyldisilazane (HMDS) catalyzed by recyclable sulfonic acid-functionalized ordered nanoporous silica

作者：Zareyee Daryoush; Karimi Babak^*

来源：Tetrahedron Letters, 2007, 48(7): 1277-1280.

DOI：10.1016/j.tetlet.2006.12.030

• solid acids
• protecting groups
• green chemistry
• solid sulphonic acid
• hexamethyldisilazane
• catalysts

Silylation of alcohols with hexamethyldisilazane (HMDS) in dichloromethane provides the corresponding silyl ethers in almost quantitative yields at room temperature using 1-3 mol% of sulfonic acid - function alized silica. Additionally, the catalyst displays a high activity and thermal stability (up to 240 degrees C) and it can be easily recovered and reused for at least 20 reaction cycles without loss of reactivity.

• 出版日期2007-2-12