Desmosomal Hotspots, Microtubule Delivery, and Cardiac Arrhythmogenesis

作者：Shaw Robin M^*

来源：Developmental Cell, 2014, 31(2): 139-140.

DOI：10.1016/j.devcel.2014.10.010

Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.

• 出版日期2014-10-27