Heme oxygenase-1 participates in the resolution of seawater drowning induced acute respiratory distress syndrome

作者：Yuan, Jia-jia; Zhang, Xiao-tong; Bao, Yun-ting; Chen, Xin-jie; Shu, Yuan-zhao; Chen, Jun-liang; Chen, Wei; Du, Bin; Pang, Qing-feng^*

来源：Respiratory Physiology & Neurobiology, 2018, 247: 12-19.

DOI：10.1016/j.resp.2017.08.016

• Seawater
• Drowning
• Acute respiratory distress syndrome
• Mice
• Heme oxygenase-1

The aim of the present study was to investigate whether heme oxygenase-1(HO-1) participated in the resolution of seawater drowning-induced acute respiratory distress syndrome (ARDS). In this study, gross and microscopic morphology of pulmonary tissue, computed tomography images and biochemical indexes were continuously observed from 15 min to 15 day after seawater drowning. The content and activity of HO-1 were determined by western-blot and spectrophotometric method, respectively. The morphological and biochemical indexes indicated that the seawater drowning could lead to the serious pulmonary hemorrhage and edema. However, 6 h after drowning, these morphological and biochemical indexes gradually returned to basal level. Meanwhile, seawater drowning increased the HO-1 expression and activity while Zinc protoporphyrin (a HO-1 specific activity inhibitor) decreased the content of transforming growth factor beta-1 in lung tissue and hampered the repair process of seawater drowning-induced ARDS. Thus, HO-1 participates in the resolution of seawater drowning-induced ARDS.

• 出版日期2018-1
• 单位江南大学