Determination and Correlation of Solubility Data and Dissolution Thermodynamic Data of Cefixime Trihydrate in Seven Pure Solvents

作者：Zhang Tianwei; Liu Quan; Xie Zhiping; Song Xiaopeng; Gong Junbo^*

来源：Journal of Chemical and Engineering Data, 2014, 59(6): 1915-1921.

DOI：10.1021/je5000605

Solvent screening plays a key role in the optimization of the drug crystallization process based on the solubility data and dissolution thermodynamic data. In this article, the solubility of cefixime trihydrate in ethanol, propan-2-ol, butan-1-ol, butan-2-ol, pentan-1-ol, ethyl acetate, and acetone from 278.15 to 323.15 K at atmospheric pressure is reported. It is found that the solubility of cefixime trihydrate in all seven solvents increases with temperature. The modified Apelblat equation fits well with the experimental solubility data in all selected solvents with the average percent deviation less than 3.5 %. The mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of cefixime trihydrate were calculated based on the van't Hoff equation. The results indicate that the dissolution process of cefixime trihydrate in all tested solvents is endothermic, entropically driven and not spontaneous.

• 出版日期2014-6
• 单位天津大学; 化学工程联合国家重点实验室