Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies

作者：van der Linden Vanessa; van der Linden Junior Helio; Leal Mariana de Carvalho; Rolim Filho Epitacio Leite; van der Linden Ana; Viana Vasco Aragao Maria de Faima; Brainer Lima Alessandra Mertens; Sousa Cruz Danielle Di Cavalcanti; Ventura Liana O; Tabosa Florencio Telma Lucia; Cordeiro Marli Tenorio; Caudas Neto Silvio da Silva; Ramos Regina Coeli

来源：Arquivos de Neuro-Psiquiatria, 2017, 75(6): 381-386.

DOI：10.1590/0004-282X20170066

• Zika virus
• Zika virus infection
• twins
• dizygotic

Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.

• 出版日期2017-6
• 单位河北医科大学