Asymmetric alkylation or silylation of (S)-(-)-diphenylprolinol-derived alpha-silyl amide to synthesize optically pure alpha-monosilyl or bis(silyl) amides

作者：Huang, Zhenggang; Gao, Lu^*; Song, Zhenlei^*

来源：Tetrahedron Letters, 2016, 57(26): 2861-2864.

DOI：10.1016/j.tetlet.2016.05.058

• Chiral organosilane
• Asymmetric alkylation
• Geminal bis(silane)

Asymmetric alkylation or silylation of (S)-(-)-diphenylprolinol-derived alpha-silyl amide has been developed to synthesize optically pure alpha-monosilyl or bis(silyl) amides in good yields with high diastereoselectivity.

• 出版日期2016-6-29
• 单位四川大学