Mitochondrial elongation during autophagy A stereotypical response to survive in difficult times

作者：Gomes Ligia C; Scorrano Luca^*

来源：Autophagy, 2011, 7(10): 1251-1253.

DOI：10.4161/auto.7.10.16771

• mitochondria
• autophagy
• fusion
• cAMP
• PKA
• DRP-1
• cell death

Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer mitochondria are protected from being degraded and possess more cristae where activity of the ATP synthase is increased, optimizing ATP production in times of nutrient restriction.

• 出版日期2011-10