Development and differentiation of early innate lymphoid progenitors

作者：Harly Christelle; Cam Maggie; Kaye Jonathan; Bhandoola Avinash

来源：Journal of Experimental Medicine, 2018, 215(1): 249-262.

DOI：10.1084/jem.20170832

<jats:p>Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.</jats:p>

• 出版日期2018-1