Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats

作者：Hino Shingo; Ito Hiroyuki; Bito Hiroyuki; Kawagishi Hirokazu; Morita Tatsuya^*

来源：Bioscience Biotechnology and Biochemistry, 2011, 75(11): 2169-2174.

DOI：10.1271/bbb.110460

• short-chain inulin-like fructans
• short-chain fatty acids
• lactobacilli
• trinitrobenzene sulfonic acid (TNBS) colitis
• rats

We evaluated the ameliorating effects of short-chain inulin-like fructans (SIF) with different degrees of polymerization (DP) on the healing stage of trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. The rats were assigned to 3 groups 10 d after the colitis induction, and fed for 24d on a control diet or diet including 60 g of DP4 or DP8/kg. The fecal myeloperoxidase (MPO) activity and IgA concentration were monitored every 7d. The colonic MPO activities and cecal concentrations of organic acids, lactobacilli, bifidobacteria, mucin and IgA were measured at the end of the study. :DP4, but not DP8, significantly reduced the colonic inflammation accompanied by higher cecal concentrations of short-chain fatty acids, propionate in particular, and lactic acid-producing bacteria. DP4 therefore accelerated the healing process of TNBS-induced colitis, even when the treatment was initiated after inducing colitis.

• 出版日期2011-11