A mitochondrial DNA variant 10398G > A in breast cancer among South Indians: An original study with meta-analysis

作者：Francis Amirtharaj; Pooja Singh; Rajender Singh; Govindaraj Periyasamy; Tipirisetti Nageswara Rao; Surekha Daminani; Rao Digumarthi Raghunatha; Rao Lakshmi; Ramachandra Lingadakai; Vishnupriya Satti; Ramalingam K; Satyamoorthy Kapaettu; Thangaraj Kumarasamy^*

来源：Mitochondrion, 2013, 13(6): 559-565.

DOI：10.1016/j.mito.2013.08.004

• Breast cancer
• mtDNA
• m.10398A &gt
• G
• Meta-analysis

The m.10398G>A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G>A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G>A polymorphism and breast cancer [OR = 0.916 (0.743-1.128); P = 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or postmenopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G>A substitution with breast cancer [OR = 1.016 (0.85-1.22); P = 0.86]. In conclusion, there is no evidence of association between m.10398G>A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.

• 出版日期2013-11
• 单位河北医科大学