A solvent-free synthesis of beta-enamino trihalomethyl ketones

作者：Martins Marcos A P^*; Peres Rodrigo L; Fiss Gabriela F; Dimer Frantiescoli A; Mayer Rodrigo; Frizzo Clarissa P; Marzari Mara R B; Zanatta Nilo; Bonacorso Helio G

来源：Journal of the Brazilian Chemical Society, 2007, 18(8): 1486-1491.

DOI：10.1590/S0103-50532007000800006

• solvent-free
• enaminones
• enones
• trihalomethyl-compounds
• green chemistry

An efficient green procedure to prepare a series of twenty-six 4-amino-1,1,1-trihalo-3-alken-2- ones [CX3C(O)CH=C(R-1)(NRR3)-R-2, where X = F, Cl, R-1 = H, Me, and R-2/R-3 = H/Ph, H/4-F-Ph, H/Bn, H/(CH2)(2)OH, Me/Ph, Me/Bu, Et/Et, -(CH2)(4)-] from the solvent-free reaction of 1,1,1-trihalo- 4-alkoxy-3-alken-2-ones with primary and secondary amines at room temperature for five minutes is reported (yields of 73-99%).

• 出版日期2007