A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model

作者：Vaish Mayank; Kleinstreuer Clement^*

来源：Journal of Biomechanical Engineering, 2015, 137(9): 094502.

DOI：10.1115/1.4030977

• lung-equivalent trumpet model
• OPENFOAM solver
• radial force function
• microsphere transport
• total lung deposition

Using the open-source software OPENFOAM as the solver, a novel approach to calculate microsphere transport and deposition in a 1D human lung-equivalent trumpet model (TM) is presented. Specifically, for particle deposition in a nonlinear trumpetlike configuration a new radial force has been developed which, along with the regular drag force, generates particle trajectories toward the wall. The new semi-empirical force is a function of any given inlet volumetric flow rate, micron-particle diameter, and lung volume. Particle-deposition fractions (DFs) in the size range from 2 lm to 10 lm are in agreement with experimental datasets for different laminar and turbulent inhalation flow rates as well as total volumes. Typical run times on a single processor workstation to obtain actual total deposition results at comparable accuracy are 200 times less than that for an idealized whole-lung geometry (i.e., a 3D-1D model with airways up to 23rd generation in single-path only).

• 出版日期2015-9