An efficient synthesis of beta-acylureas via a three-component, one-pot synthesis using TCS/ZnCl2

作者：Khatab Tamer K^*; El Bayouki Khairy A M; Basyouni Wahid M

来源：Tetrahedron Letters, 2011, 52(13): 1448-1451.

DOI：10.1016/j.tetlet.2011.01.066

• beta-Acylureas
• Tetrachlorosilane
• Multicomponent reactions

A simple and efficient one-pot, three-component synthesis of new trisubstituted ureas containing diastereotopic protons is achieved via the reaction of aromatic aldehydes, aromatic ketones, and dimethyl cyanamide using a TCS/ZnCl2 reagent mixture at room temperature.

• 出版日期2011-3-30