New Terpenoids from Croton limae (Euphorbiaceae)

作者：Sousa Antonio H; Silva Junior Jose N; Guedes Maria L S; Braz Filho Raimundo; Costa Lotufo Leticia V; Araujo Ana J; Silveira Edilberto R; Lima Mary A S^*

来源：Journal of the Brazilian Chemical Society, 2015, 26(8): 1565-1572.

DOI：10.5935/0103-5053.20150124

• Croton limae
• diterpenes
• terpenoid adduct
• cytotoxic activity

An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin-3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50 values of 7.14, 8.19 and > 10 mu g mL(-1), respectively.

• 出版日期2015-8