A Green Method for Synthesis of 7H-thiazolo[3,2-b][1,2,4]-triazin-7-one Derivatives as AChE Inhibitors

作者:Liu Sijie*; Zhang Baohua; Jia Pengfei; Niu Nan; He Jingyu; Shi Lanxiang
来源:International Conference on Energy, Materials and Manufacturing Engineering (EMME), 2015-10-15 to 2015-10-16.
DOI:10.1051/matecconf/20152502002

摘要

The authors study an efficient and green approach for the synthesis of 7H-thiazolo [3, 2-b][1,2,4]triazin-7-one derivatives as AChE inhibitors. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones were designed by molecular docking, and readily prepared via a one-pot reaction in morpholine hydrosulfate ([Hnhm]HSO4) ionic liquid as the catalyst and solvent. The study of AChE inhibitory activity was carried out through using the Ellman colorimetric assay. The 7H-thiazolo[3,2-b][1,2,4]triazin-7-ones had been successfully synthesized by green catalyst. Most of the target compounds exhibited more than 50% inhibition at 10 mu M.

  • 出版日期2015
  • 单位石家庄学院

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