New approach for the synthesis of 3H-pyrrolo[2,3-c]isoquinoline derivatives

作者：Dixit Bharat; Balog Jozsef; Riedl Zsuzsanna; Drahos Laszlo; Hajos Gyoergy^*

来源：Tetrahedron, 2012, 68(18): 3560-3565.

DOI：10.1016/j.tet.2012.03.011

• Fused pyrrole
• Iodination
• Cyclization
• Buchwald-Hartwig cross-coupling
• Sonogashira cross-coupling

Synthesis of new 2,3-diaryl-3H-pyrrolo[2,3-c]isoquinoline derivatives has been elaborated starting from isoquinoline-3-amine. Buchwald-Hartwig arylation and subsequent iodination in position 4 afforded 3-arylamino-4-iodoisoquinolines. These compounds were subjected to Sonogashira cross-coupling reactions with some selected acetylenes, and the resulting coupled products underwent cyclization in the presence of tetrabutylammonium fluoride to give title derivatives.

• 出版日期2012-5-6