HO-1(hi) patrolling monocytes protect against vaso-occlusion in sickle cell disease

作者：Liu Yunfeng; Jing Fangmiao; Yi Woelsung; Mendelson Avital; Shi Patricia; Walsh Ronald; Friedman David F; Minniti Caterina; Manwani Deepa; Chou Stella T; Yazdanbakhsh Karina

来源：Blood, 2018, 131(14): 1600-1610.

DOI：10.1182/blood-2017-12-819870

<jats:title>Key Points</jats:title>
<jats:p>SCD patients with a recent VOC episode have lower frequencies and numbers of HO-1hi patrolling monocytes. Heme-driven SCD vaso-occlusion is exacerbated in mice lacking patrolling monocytes and reversed following patrolling monocyte transfer.</jats:p>

• 出版日期2018-4-5