科研之友
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摘要
Due to limited available antifungal agents, searching for new antifungal agents stimulated research on new chemotherapeutic agents in natural products. The current study was carried out to assess the antifungal activity of different Iranian honeys with different botanical origin against some important fungi, such as azoles-resistant Candida species. Seven types of honey samples including Thymus vulgaris,Alfalfa, Citrus, Zizyphus, Astragalus,Chamaemelum nobile and multiflora honey were collected. Minimum inhibitory concentrations microdilution broth method was used for assessing antifungal activity of honeys. The results revealed variations in the antifungal activity of the examined honey samples. Alfalfa and Thymus honeys were significantly more effective than other honeys and Zizyphus and Chamaemelum honeys exhibited lowest antifungal activity. Trichophyton rubrum and C.krusei had the highest and lowest sensitivity to the honey's antifungal activity among fungal species, respectively. No statistically significant differences in susceptibility to honey samples were determined among fluconazole resistance and susceptible Candida species.
- 出版日期2014-10
