Building a Framework for Embryonic Microenvironments and Cancer Stem Cells

作者：Ruiz Vela Antonio; Aguilar Gallardo Cristobal; Simon Carlos^*

来源：Stem Cell Reviews and Reports, 2009, 5(4): 319-327.

DOI：10.1007/s12015-009-9096-7

• Embryonic stem cells
• Cancer stem cell
• Niches
• Microenvironment
• Reprogramming

The putative existence of a cancer stem cell niche consisting of bi-directional stromal and stem cell secreting factors that trigger cancer stem cell growth and proliferation has been hypothesized in the nervous and hematopoietic systems. In light of this theory, it has been proposed that embryonic stem cell microenvironments, upon interactions with cancer stem cells, may reprogram cancer cells resulting in a substantial inhibition of tumor cell properties. Here, we discuss emerging data that support this novel concept of cancer inhibitory factors produced in the context of embryonic microenvironments as well as by embryonic stem cells (ESCs).

• 出版日期2009-12