Association of metabolic complications with plasma mid-regional pro-adrenomedullin level in stable kidney transplant recipients

作者：Suzuki Yosuke^*; Katagiri Fumihiko; Sato Fuminori; Fujioka Takashi; Tanaka Ryota; Sato Yuhki; Mimata Hiromitsu; Itoh Hiroki

来源：Clinica Chimica Acta, 2016, 453: 160-163.

DOI：10.1016/j.cca.2015.12.016

• Mid-regional pro-adrenomedullin
• Metabolic complications
• Hypertension
• Hyperlipidemia
• Kidney transplantation

Background: Recently, increased plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations have been demonstrated in patients with chronic renal failure. In this study, we attempted to identify significant clinical factors associated with MR-proADM concentration in stable kidney transplant recipients.
Methods: Forty-seven Japanese kidney transplant recipients who underwent transplantation >180 days prior to the study were analyzed. To facilitate comparability of anti-hypertensive regimens across recipients taking different drugs, we calculated the treatment intensity score of anti-hypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM concentrations were measured using an enzyme immunoassay.
Results: Multiple regression analysis identified treatment intensity score for anti-hypertensive drugs, serum albumin, creatinine clearance and use of lipid-lowering agents as significant independent factors associated with plasma MR-proADM concentration. Adjusted coefficient of determination for this model was 0.46.
Conclusion: Apart from indicating lowered renal function, plasma MR-proADM concentration may be a useful biomarker for metabolic disorders, especially hypertension and hyperlipidemia, in stable kidney transplant patients.

• 出版日期2016-1-30