Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats

作者：Benites Julio^*; Bustos Luis; Rios David; Bravo Felipe; Lopez Jose; Gajardo Sandra; Rojo Leonel; Buc Calderon Pedro

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2013, 12(4): 413-419.

• Acantholippia deserticola
• Verbenacea
• thujone
• anxiolytic and antidepressant effects

Acantholippia deserticola (Phil. ex F. Phil.) Moldenke is a Verbenaceae that has long been used in traditional medicine in Tarapaca (Chile) as an analgesic, anti-inflammatory and aphrodisiac agent. Since alpha- and beta-thujone were identified as the main constituents (88.4%) of the essential oil from this plant, we investigated its biological properties. The results show that the essential oil from Acantholippia deserticola decreased locomotive and rearing activity compared to control group rats, including those treated with diazepam, but the essential oil had no effects on head movements or grooming. The essential oil also had significant anxiolytic and antidepressant effects. This essential oil, therefore, has sedative, anxiolytic and antidepressant actions on the rat central nervous system.

• 出版日期2013-7