Dopamine release in nucleus accumbens during rewarded task switching measured by [C-11]raclopride

作者：Jonasson Lars S^*; Axelsson Jan; Riklund Katrine; Braver Todd S; Ogren Mattias; Backman Lars; Nyberg Lars

来源：NeuroImage, 2014, 99: 357-364.

DOI：10.1016/j.neuroimage.2014.05.047

• Reward
• Dopamine
• PET
• Nucleus accumbens
• Working memory
• Motivation

Reward and motivation have positive influences on cognitive-control processes in numerous settings. Models of reward implicate corticostriatal loops and the dopamine (DA) system, with special emphasis on D-2 receptors in nucleus accumbens (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with positron emission tomography (PET) in a single [C-11]raclopride dynamic scan during rewarded and non-rewarded task switching. Rewarded task switching (relative to baseline task switching) decreased [11C]raclopride binding in NAcc. Decreasing NAcc [C-11]raclopride binding was strongly associated with task reaction time measures that reflect individual differences in effort and control strategies. Voxelwise analyses additionally revealed reward-related DA release in anterodorsal caudate, a region previously associated with task-switching. These PET findings provide evidence for striatal DA release during motivated cognitive control, and further suggest that NAcc DA release predicts the task reaction time benefits of reward incentives.

• 出版日期2014-10-1