Pathophysiology and animal modeling of underactive bladder

作者：Tyagi Pradeep; Smith Phillip P; Kuchel George A; de Groat William C; Birder Lori A; Chermansky Christopher J; Adam Rosalyn M; Tse Vincent; Chancellor Michael B^*; Yoshimura Naoki

来源：International Urology and Nephrology, 2014, 46(S1): S11-S21.

DOI：10.1007/s11255-014-0808-9

• Detrusor
• Underactivity
• Animal model
• Surrogate

While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

• 出版日期2014-9