Different synaptic mechanisms of long-term potentiation induced by nicotine and tetanic stimulation in hippocampal CA1 region of rats

作者：He, J; Deng, CY; Zhu, XN; Yu, JP; Chen, RZ^*

来源：Acta Pharmacologica Sinica, 2003, 24(5): 398-402.

• nicotine
• long-term potentiation
• hippocampus
• MK-801
• L-NAME

Aim: To investigate whether long-term potentiation (LTP) induced by nicotine and tetanic stimulation in the hippocampal CA1 region shares different mechanisms. Methods: Extracellular population spikes of the pyramidal cell layer in the hippocampal CA1 region were recorded in vitro. Results: LTP induced by the tetanic stimulation could be facilitated by nicotine 10 mumol/L, meanwhile, the tetanic stimulation did the same effect on LTP induced by nicotine 10 mumol/L. MK-801 10 mumol/L or N-G-nitro-L-arginine methyl ester (L-NAME) 20 mumol/L blocked LTP induced by tetanic stimulation, but did not inhibit LTP induced by nicotine. Conclusion: LTP induced by nicotine shares different synaptic mechanisms with LTP induced by tetanic stimulation.

• 出版日期2003-5
• 单位中山大学