Water-soluble Bis(thiosemicarbazonato)copper(II) Complexes

作者：Buncic Gojko; Hickey James L; Schieber Christine; White Jonathan M; Crouch Peter J; White Anthony R; Xiao Zhiguang; Wedd Anthony G; Donnelly Paul S^*

来源：Australian Journal of Chemistry, 2011, 64(3): 244-252.

DOI：10.1071/CH10463

The synthesis of four new water-soluble bis(thiosemicarbazone) ligands and their copper(II) complexes is presented and their potential to be new ligands for copper radiopharmaceuticals is discussed. The ligands and complexes have been characterized by a combination of NMR spectroscopy, mass spectrometry, and X-ray crystallography. The electrochemical behaviour of two of the copper(II) complexes was investigated by cyclic voltammetry and revealed that both complexes exhibited a quasi-reversible redox process attributed to a Cu-II/Cu-I process. Two of the new ligands were radiolabelled with positron-emitting Cu-64 with a view to assessing their potential as ligands that bind radioactive copper isotopes for application in diagnostic radiopharmaceuticals. The cellular uptake of the copper complexes was investigated in SH-SY5Y cells.

• 出版日期2011