Differential effects of seizure control and affective symptoms on quality of life in people with epilepsy

作者：Park Sung Pa^*; Song Hyun Seok; Hwang Yang Ha; Lee Ho Won; Suh Chung Kyu; Kwon Soon Hak

来源：Epilepsy and Behavior, 2010, 18(4): 455-459.

DOI：10.1016/j.yebeh.2010.05.021

• Seizure control
• Affective symptoms
• Depression
• Anxiety
• Quality of life
• Epilepsy

Objective: The purpose of the study was to delineate how affective symptoms (AS) influence quality of life (QOL) for individuals with drug-refractory epilepsy (DRE) and those with well-controlled epilepsy (WCE) independently.
Methods: All subjects participating in the study were asked to complete reliable and validated self-report health questionnaires, including AS, measured with the Korean versions of the Beck Depression Inventory, Beck Anxiety Inventory, and Quality of Life in Epilepsy Inventory-31 (QOLIE-31). We examined predictors of QOLIE-31 scores among the various demographic and clinical factors. We compared the effects of AS on QOL between patients with DRE and those with WCE and investigated the differential effects of seizure control and AS on QOL.
Results: Two hundred forty-nine patients with ORE or WCE were included in the study. The strongest predictor of QOL was AS, followed by seizure control and MRI abnormality. Affective symptoms had almost two times the effect of seizure control and six times the effect of MRI abnormality. Poorest QOL was noted in patients with ORE with AS, followed by those with WCE with AS, ORE without AS, and WCE without AS.
Conclusion: The major determinant of QOL in patients with epilepsy is AS rather than ORE or WCE status.

• 出版日期2010-8