An Association Study of the Genetic Polymorphisms in 13 Neural Plasticity-Related Genes with Semantic and Episodic Memories

作者：Gong, Pingyuan; Zheng, Zijian; Chi, Wanyu; Lei, Xu; Wu, Xiaodong; Chen, Dongmei; Zhang, Kejin; Zheng, Anyun; Gao, Xiaocai; Zhang, Fuchang^*

来源：Journal of Molecular Neuroscience, 2012, 46(2): 352-361.

DOI：10.1007/s12031-011-9592-5

• Semantic memory
• Episodic memory
• Functional variants
• Neural plasticity

Semantic and episodic memories were two different attributes of long-term memory. In the past few years, plenty of physiological evidence has indicated that neural plasticity is involved in the formation of long-term memory. In the present study, we hypothesized that some functional variants of neural plasticity-related genes were related to episodic and semantic memories. To confirm this hypothesis, we examined the relationship of 13 plasticity-related genes with episodic and semantic memories. The results indicated that there was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6 (chi(2)=16.638, p=0.0002). However, the functional variations in BDNF, COMT, DBH, DRD2, DRD3, DRD4, MAOA, TPH2, 5-HT2A, GRM(1), and GRIN2B had no observable effects on the memories. Our preliminary results confirm the hypothesis that a small number of functional variants of the neural plasticity-related genes, such as T267C in 5-HT6, play important roles in human specific memory.

• 出版日期2012-2
• 单位西北大学; 河南大学