Development of strong, biodegradable and highly elastomeric polycitrate-gelatin hybrid polymer with enhanced cellular biocompatibility

作者：Feng, Caiting; Du, Yuzhang; Li, Yannan; Lei, Bo^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2017, 75: 1339-1342.

DOI：10.1016/j.msec.2017.03.053

• Hybrid elastomers
• Polycitrate
• Mechanical properties
• Tissue regeneration

Native human tissues possess incomparable biological performance due to their strong and viscoelastic mechanical properties, and biocompatible compositions. Herein, by a thermal polymerization and solvent hybridization method, we develop biomimetic polycitrate-gelatin hybrid polymers (PC-GT) with strong mechanical properties and tailored elastomeric behavior for tissue regeneration applications. The incorporation of gelatin significantly enhanced the mechanical properties and cellular biocompatibility of PC. PC-GT hybrids demonstrated the 135 times (from 7.5 to 1015 MPa) and 11 times (from 4 to 46 MPa) improvement for the elastomeric modulus and tensile strength respectively as compared with PC elastomers, while showing controlled stretchable and elastomeric behavior. In addition, PC-GT hybrids significantly improved the fibroblasts (L929) attachment and proliferation, suggesting their high biocompatibility. This study may provide a novel strategy to design biocompatible hybrid polymers with strong and elastomeric behavior for tissue regeneration and stretchable electronic devices applications.

• 出版日期2017-6-1
• 单位周口师范学院; 西安交通大学