Ultrasound evaluation of liver fibrosis: preliminary experience with acoustic structure quantification (ASQ) software

作者：Ricci Paolo^*; Marigliano Chiara; Cantisani Vito; Porfiri Andrea; Marcantonio Andrea; Lodise Pietro; D'Ambrosio Ugo; Labbadia Giancarlo; Maggini Elena; Mancuso Ester; Panzironi Giovanna; Di Segni Mattia; Furlan Caterina; Masciangelo Raffaele; Taliani Gloria

来源：Radiologia Medica, 2013, 118(6): 995-1010.

DOI：10.1007/s11547-013-0940-0

• Acoustic structure quantification
• Liver fibrosis
• Fibroscan

The aim of our study was to assess the diagnostic accuracy of acoustic structure quantification (ASQ) ultrasound software in estimating the degree of hepatic fibrosis compared to Fibroscan and liver biopsy.
Seventy-seven patients with chronic viral hepatitis B and C underwent standard ultrasound examination, ASQ, Fibroscan and liver biopsy. ASQ analysis was conducted by placing a single region of interest (ROI) on each image captured, and calculating mode, average and standard deviation. The sonographic technique was developed through a preliminary evaluation of 20 healthy volunteers.
The area under the receiver operating characteristic (AUROC) curve for the diagnosis of cirrhosis (Fa parts per thousand yen4) with ASQ was 0.77, whereas for the diagnosis of any degree of fibrosis (Fa parts per thousand yen1) it was 0.71. The AUROC for the diagnosis of cirrhosis (Fa parts per thousand yen4) with Fibroscan was 0.98, while for the diagnosis of any degree of fibrosis (Fa parts per thousand yen1) it was 0.94. The difference between the AUROC was statistically significant (p < 0.05).
ASQ is a promising new ultrasound software programme which offers encouraging results in the diagnosis of both liver cirrhosis (F=4) and fibrosis (Fa parts per thousand yen1). However, to date it has not attained the same level of diagnostic performance as Fibroscan.

• 出版日期2013-9