Microwave-assisted, montmorillonite K-10 catalyzed three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

作者：Reddy Mudumala Veeranarayana; Reddy Gangireddy Chandra Sekhar; Jeong Yeon Tae^*

来源：Tetrahedron, 2012, 68(34): 6820-6828.

DOI：10.1016/j.tet.2012.06.045

• 2H-indazolo[2,1-b]phthalazine-triones
• Montmorillonite K-10
• Microwave irradiation
• Solvent-free reaction

An efficient, rapid, and green synthesis of 2H-indazolo[2,1-b]phthalazine-triones has been accomplished under solvent-free conditions by the reaction of phthalhydrazide, aldehydes and 5,5-dimethylcyclohexane-1,3-dione. This approach exploits the synthetic potential of microwave irradiation and Montmorillonite K-10 combination and offers many advantages, such as excellent product yields, shorter reaction time, reusable catalyst, easy isolation of products, and environmentally benign reaction conditions.

• 出版日期2012-8-26