Nanobiomaterials: State of the Art and Future Trends

作者：Yang Lei^*; Zhang Lijuan; Webster Thomas J

来源：Advanced Engineering Materials, 2011, 13(6): B197-B217.

DOI：10.1002/adem.201080140

In the past decade, it is clear that the development of biomaterials has entered the "nanotechnology era.'' The interface between biomaterials and nanotechnology has created enormous opportunities to improve the prevention, diagnosis, and treatment of numerous diseases. Nanobiomaterials, a new term describing biomaterials with constituent or surface feature sizes less than 100 nm (10(-7) m), provide not only extraordinary materials with unique structures and properties to solve our most traditional biomedical puzzles, but also provide unprecedented knowledge and principles toward understanding biology, medicine, and materials science. At the commencement of the second decade of the new millennium, it is worthwhile to review the current state of the art for the use of nanobiomaterials in medicine as well as possible future trends. Therefore, this paper seeks to summarize the current advances in nanobiomaterials research, spanning a wide range of tissue engineering applications (both soft and hard tissues), drug delivery, disease detection, and disease treatment. In addition, emerging concerns on the safety of manufacturing and using nanobiomaterials (especially toxicological issues) with necessary future research directions from the design of intelligent nanobiomaterials to molecular mechanisms of cell-nanomaterial interactions are also discussed.

• 出版日期2011-6