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摘要
Rapid and efficient solvent-free one-pot synthesis of dialkylamino alkyl-1-(4-bromobenzylidene) phosphonohydrazone derivatives by the condensation reaction of N, N-dialkylamino allcylphosphorohydrazides with p-bromobenzaldehyde using silica under microwave irradiation is described. The structural features of the synthesized compounds were characterized by IR, H-1-NMR, C-13-NMR, mass spectroscopy and elemental analysis. The newly synthesized compounds were screened for antimicrobial activity against two Gram-positive strains (Staphylococcus aureus and Bacillus sublitis) and two Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). The results showed that some of these compounds were active against all tested bacteria.
- 出版日期2014
