Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

Figee Martijn<sup>*</sup>; Luigjes Judy; Smolders Ruud; Valencia Alfonso Carlos Eduardo; van Wingen Guido; de Kwaasteniet Bart; Mantione Mariska; Ooms Pieter; de Koning Pelle; Vulink Nienke; Levar Nina; Droge Lukas; van den Munckhof Pepijn; Schuurman P Richard; Nederveen Aart; van den Brink Wim; Mazaheri Ali; Vink Matthijs; Denys Damiaan

doi:10.1038/nn.3344

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Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

作者：Figee Martijn^*; Luigjes Judy; Smolders Ruud; Valencia Alfonso Carlos Eduardo; van Wingen Guido; de Kwaasteniet Bart; Mantione Mariska; Ooms Pieter; de Koning Pelle; Vulink Nienke; Levar Nina; Droge Lukas; van den Munckhof Pepijn; Schuurman P Richard; Nederveen Aart; van den Brink Wim; Mazaheri Ali; Vink Matthijs; Denys Damiaan

来源：Nature Neuroscience, 2013, 16(4): 386-U195.

DOI：10.1038/nn.3344

摘要

Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.