Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats

作者：Verma Ramesh; Brahmankar Mahesh; Kushwah Lokendra; Suresh Balakrishnan^*

来源：Environmental Toxicology and Pharmacology, 2013, 36(3): 769-778.

DOI：10.1016/j.etap.2013.07.011

• Bleomycin
• Lung fibrosis
• Sulindac
• Hydroxyproline
• Tumour necrosis factor-alpha

The present study examined the protective effect of sulindac on bleomycin-induced lung fibrosis in rats. Animals were divided into saline group, bleomycin group (single intratracheal instillation of bleomycin) and bleomycin + sulindac (orally from day 1 to day 20). Bleomycin administration reduced the body weight, altered antioxidant status (such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione) while it increased the lung weight, hydroxyproline content, collagen deposition and lipid peroxidation. However, simultaneous administration of sulindac improved the body weight, antioxidant status and decreased the collagen deposition in lungs. Moreover, the levels of inflammatory cytokine tumour necrosis factor-alpha increased in bleomycin-induced group, whereas, on treatment with sulindac the levels of tumour necrosis factor-alpha were found reduced. Finally, histological evidence also supported the ability of sulindac to inhibit bleomycin-induced lung fibrosis. The results of the present study indicate that sulindac can be used as an agent against bleomycin-induced pulmonary fibrosis.

• 出版日期2013-11